Li Y, Jin M, O'Laughlin R, Bittihn P, Tsimring LS, Pillus L, Hasty J, Hao N. Multi-generational silencing dynamics control cell aging. Proc Natl Acad Sci U S A. 2017. Accepted.

Shao B, Yuan H, Zhang R, Wang X, Zhang S, Ouyang Q, Hao N*, Luo C*. Reconstructing the regulatory circuit of cell fate determination in yeast mating response. PLoS Comput Biol. 2017 Jul; 13(7):e1005671. (pdf) (* co-correspondence)

Jiang Y, AkhavanAghdam Z,Tsimring LS, Hao N. Coupled feedback loops control the stimulus-dependent dynamics of the yeast transcription factor Msn2. J Biol Chem. 2017 Jun; 292(30):12366-12372. (pdf)

Zhang R, Yuan H, Wang S, Ouyang Q, Chen Y, Hao N, Luo C. High-throughput single-cell analysis for the proteomic dynamics study of the yeast osmotic stress response. Sci Rep. 2017 Feb;7:42200. (pdf)


AkhavanAghdam Z, Sinha J, Tabbaa OP, Hao N. Dynamic control of gene regulatory logic by seemingly redundant transcription factors. eLife 2016 Sep;5. (pdf)

Yuan H, Zhang R, Shao B, Wang X, Ouyang Q, Hao N, Luo C. Protein expression patterns of the yeast mating response. Integr Biol. 2016 Jun;8(6):712-9. (pdf)


Hansen AS, Hao N, O’Shea EK. High-throughput microfluidics to control and measure signaling dynamics in single yeast cells. Nat Protoc. 2015 Aug;10(8):1181-97. (pdf)

2013 and before

Hao N, Budnik BA, Gunawardena J, O’Shea EK. Tunable signal processing through modular control of transcription factor translocation. Science 2013 Jan 25; 339(6118):460-4.

Hao N, Yildirim N, Nagiec MJ, Parnell SC, Errede B, Dohlman HG, Elston TC. Combined computational and experimental analysis reveals MAP kinase-mediated feedback phosphorylation as a mechanism for signaling specificity. Mol Biol Cell. 2012 Oct;23(19):3899-910.

Hao N, O'Shea EK. Signal-dependent dynamics of transcription factor translocation controls gene expression. Nat Struct Mol Biol. 2011 Dec 18;19(1):31-9.

Hao N, Zeng Y, Elston TC, Dohlman HG. Control of MAPK specificity by feedback phosphorylation of shared adaptor protein Ste50. J Biol Chem. 2008 Dec 5;283(49):33798-802.

Behar M, Hao N, Dohlman HG, Elston TC. Dose-to-duration encoding and signaling beyond saturation in intracellular signaling networks. PLoS Comput Biol. 2008 Oct;4(10):e1000197.

Hao N, Nayak S, Behar M, Shanks RH, Nagiec MJ, Errede B, Hasty J, Elston TC, Dohlman HG. Regulation of cell signaling dynamics by the protein kinase-scaffold Ste5. Mol Cell. 2008 Jun 6;30(5):649-56.

Behar M, Hao N, Dohlman HG, Elston TC. Mathematical and computational analysis of adaptation via feedback inhibition in signal transduction pathways. Biophys J. 2007 Aug 1;93(3):806-21.

Hao N, Behar M, Elston TC, Dohlman HG. Systems biology analysis of G protein and MAP kinase signaling in yeast. Oncogene 2007 May 14;26(22):3254-66. Review.

Hao N, Behar M, Parnell SC, Torres MP, Borchers CH, Elston TC, Dohlman HG. A systems-biology analysis of feedback inhibition in the Sho1 osmotic-stress-response pathway. Curr Biol. 2007 Apr 17;17(8):659-67.

Chasse SA, Flanary P, Parnell SC, Hao N, Cha JY, Siderovski DP, Dohlman HG. Genome-scale analysis reveals Sst2 as the principal regulator of mating pheromone signaling in the yeast Saccharomyces cerevisiae. Eukaryot Cell 2006 Feb;5(2):330-46.

Wang X, Hao N, Dohlman HG, Elston TC. Bistability, stochasticity, and oscillations in the mitogen-activated protein kinase cascade. Biophys J. 2006 Mar 15;90(6):1961-78.

Yildirim N, Hao N, Dohlman HG, Elston TC. Mathematical modeling of RGS and G-protein regulation in yeast. Methods Enzymol. 2004;389:383-98. Review.

Hao N, Yildirim N, Wang Y, Elston TC, Dohlman HG. Regulators of G protein signaling and transient activation of signaling: experimental and computational analysis reveals negative and positive feedback controls on G protein activity. J Biol Chem. 2003 Nov 21;278(47):46506-15.